Players can use weapons such as crowbars, baseball bats, and knives to kill various bikers, gang members, and thugs. Players can trigger close-up, slow motion attacks that often result in bones snapping or enemies getting stunned. Punches and melee attacks frequently cause splashes of red blood to fly through the air, while floors/walls are sometimes stained with pools of blood.

During the course of the game, players must track down a villain who has molested an actress appearing in a pornography film. The search leads players to a strip club that contains go-go dancers in cages, peep-show booths, and a pornographic film playing in the background. Although moaning and suggestive dialogue (e.g., "Ohhh, it's so big!") can be heard echoing from the film, no nudity or sexual acts are depicted. Some strong profanity (e.g., "f*ck" and "sh*t") can be heard in the dialogue.

Watchmen: The End is Nigh Part II is in development for PS3, X360, and PC, but has no release date set yet.