Years have passed; violence and instability have started to beleaguer developed nations. People with crazed and distorted smiles are appearing throughout the world. Anyone with this ‘Heaven’s Smile’ becomes violent and begins attacking anybody within close proximity. Now these crazed soldiers have started to overthrow huge city governments and have even taken the life of Harman’s beloved Suzy. It is up to the player to utilize the special powers that dwell within Harman’s seven ‘partners’ to assassinate the powerful underworld kingpin behind it all, Kun Lan.