No More Heroes tells the story of Travis Touchdown, an anime fan who lives in the fictional town of Santa Destroy, California. After an unexpected turn of events, Travis finds himself at the bottom of an Assassins' organization. Travis will have to prove himself worthy and defeat 10 other bloodthirsty killers, all with deep stories of their own, to make his way to the top of the assassin's league.

No More Heroes realizes the dream of Wii players everywhere, as they can wield the Wii Remote to swing Travis' beam katana and perform spectacular wrestling moves. Suda 51's creation features avant-garde graphics that will thrust players into a stylized world filled with edgier gameplay.