In New York City, beggars are disappearing one after another, only to be found burnt alive. Meanwhile, a Y-shaped scar forms in the palm of the hands of seemingly unrelated people. With the police and the media giving little attention to these events, Henry White, a young and rich heir dedicated to a charitable organization, and his friend Cooper, are the first to investigate these disappearances. They are two of the three playable characters in Yesterday, the third being none other than the enigmatic John Yesterday, who is dragged into this incredible story after his memory is completely wiped.