After recuing people from a bus wreck, 24-year-old Delsin Rowe discovers that he can control and transform into smoke. Could he have absorbed this power from one of the passengers of the wreckage?

It's been seven years since the last game, and the world has changed. Anyone who shows signs of being a "bio-terrorist" is handed to the Department of Unified Protection (DUP). Delsin is caught in the dragnet.

The path, gameplay and story depend on decisions that you make along the way. As you play, you'll explore many of Seattle's landmarks.