At Anime Expo 2015 Aksys Games announced that it is bringing Zero Escape Volume 3 to North America.

Nine people have been sent to the Mars Mission Test Site to simulate a manned mission to Mars. On December 31, 2028, the day the simulation was going to end, an unknown group (Most likely Free the Soul) hacks into an operator's video feed of the simulation and release Radical-6 into the facility. All but 3 people die, the survivors being a woman (Diana) and two other unknown people (Most likely Sigma and Phi). The woman contacts the operator, ominously saying that she killed the 6 people, and will likely kill 6 billion more people. This is presumably when Radical-6 escapes from the facility.

It is up to the Espers of Akane Kurashiki's group to stop Radical-6 from escaping.

Many government organizations have dismissed our urgent warnings regarding the upcoming game event called Zero Time Dilemma. Recent intelligence has escalated our plans and we have come to the decision to contact gamers about the dangers directly. Our ultimate goal has always been to protect the public from the horrific consequences we have foreseen, but it appears our mission to prevent it from occurring may have failed. It is imperative that you make every effort to prepare yourselves for the oncoming deadly game, so that you may survive the coming apocalypse.

An antidote for the game is predicted to be created, but much further down this timeline, and as such there is no defense from its effects. It will be most easily identifiable on Nintendo 3DS™ and PlayStation®Vita handheld entertainment system, though it is transmittable through the air so the spread may increase even more rapidly through the PlayStation®Store and Nintendo eShop.

Do not be tempted by familiar faces, fully voiced cinematics, multiple endings, or voices in both Japanese and English, as those are signs that the apocalypse is nigh. We suggest that you put extensive effort into improving your puzzle solving skills, as they will be vital to your survival.

We at Crash Keys beg for your assistance in notifying everyone you can so that no one is left in the dark about this dangerous game. The world will end up in a tumultuous uproar, and ultimate consequences will be unavoidable unless word gets out. Use all the time available to you before the summer of next year to contact your loved ones and prepare; our intelligence hasn’t been able to focus in on an exact date at this time. Do not fear – we are here to protect you and prepare you to our utmost ability so that you may survive. You will survive. We will use all channels available to contact you with updates as soon as we uncover them. You must be ready.