After selecting a main character, players will duke it out while charging up the abilities of their two chosen Partners, who - once called into the fight - will contribute with battle damage and various other effects. As the combatants exchange blows, their Power Gauge builds at the bottom of the screen. Filling this gauge meter by meter, up to a maximum of three, the players will then gain access to devastating abilities, including character-specific super moves and a massively powerful "Lethal Blaze" attack that deals incredible damage but costs all three meters.

Also included is an innovative "Blast" system, which provides players with the option to use one of three special tide-turning maneuvers once per round, such as creating distance between the player character and her opponent, breaking an opponent's combo, and extending a player's combo beyond normal limits. Additionally, a player's health and meters both begin regenerating once the Blast state has been activated.

Between easy-to-execute combos, cinematic cut-ins on "Lethal Blaze" attacks that run the gamut from awe-inspiring to adorable, and assist mechanics that allow for up to six on-screen characters at a time, the development team at EXAMU ensures that combat in Nitroplus Blasterz: Heroines Infinite Duel stays fast and flashy. The game is populated by numerous heroines from the visual novel company Nitroplus' rich collection of IPs, including playable characters Ein, Mora, Ruili, Al Azif, Saya, Ignis, Anna, Muramasa the 3rd, Kibanohara Ethica, Saber, and Ouka, as well as fan favorite mascot character Super Sonico, who will be playable in Nitroplus Blasterz for the very first time via this console release. Players can also test how their skills stack up online against other network players, with full cross-play compatibility on offer between PS4 and PS3 system users.

XSEED Games will be offering the game's two DLC characters Homura (from the SENRAN KAGURA series) and Aino Heart (from the Arcana Heart series) free of charge on the PlayStation Store for the first four weeks following their respective release dates. Starting March 1, Homura and Aino Heart will be available for $5.99 each or as a bundle for $9.99.

Nitroplus Blasterz: Heroines Infinite Duel will be available for $39.99 on the PS4 for both the physical and digital release, while the PS3 version will be released exclusively on the PlayStation Store at $29.99.