Metal Gear Survive picks up from the ending of Metal Gear Solid V: Ground Zeroes, to an alternate timeline caused by unexplained wormholes forming in the sky. Players find themselves on distorted desert landscapes full of massive half-formed structures, living biological threats, and the remains of a once strong military force now litter the landscape.

In a struggle to stay alive on this harsh terrain filled with deadly creatures, soldiers who were previously on Motherbase now must work cooperatively in order to survive. Metal Gear Survive continues the pedigree of Metal Gear Solid V's gameplay design, with a unique blend of stealth and co-op play mechanics. Players can strategically manage massive threats with the help of four-player online cooperative play. New weaponry will also be introduced to combat charging creatures and lethal environments as well.