The goal is to raise $1 million to benefit the lifesaving mission of St. Jude Children’s Research Hospital®: Finding cures. Saving children.

This year’s stream will be bigger than ever with top-tier guests appearing during the 10-hour event to fundraise through interactive competitions, musical performances and video game face-offs. The livestream will also feature heartwarming patient stories. After raising $3.1 million last year to help end childhood cancer and other life-threatening diseases, The Game Theory $1,000,000 Challenge was recognized with the 2021 Streamy Award for Social Good.

“MatPat and Stephanie are true friends to the kids of St. Jude. We’re in awe of the ingenious and fun ways they have engaged other content creators from around the world year after year,” said Richard C. Shadyac Jr., President and CEO of ALSAC, the fundraising and awareness organization for St. Jude Children’s Research Hospital. “The selfless support of the gaming community helps make it possible for St. Jude Children’s Research Hospital to continue accelerating its research and delivering lifesaving treatment to help kids around the globe as outlined in its six-year, $11.5 billion strategic plan.”

This year the content creator duo will be joined by guests Alex Hirsch, Aphmau, Binging with Babish, CaptainSparklez, Corpse Husband, DanTDM, Dawko, Derek Muller, Dream, GeorgeNotFound, Jaiden Animation, Jake Roper (Vsauce 3), Jason Ritter, Keith Habersberger (Try Guys), Louis Weisz, Mark Rober, Markiplier, Marques Brownlee, Matt Amodio, Mr Beast, Ned Fulmer (Try Guys), Odd1sOut, Rhett & Link, Rosanna Pansino, Safiya Nygaard, Sapnap, Simone Giertz, Tommyinit, Tubbo, Tyler Williams, Wilbur Soot, William Osman, ZHC and others.

For every $10 donation, viewers will be entered into a giveaway to win one of several prizes. The stream’s top 100 donors will receive a limited-edition gold foil shirt, and the top 10 individual donors will receive an event hoodie.

YouTube Originals is the title sponsor of this year’s event and welcomes the support of other corporate partners including Leslie’s Pool Supplies, American Airlines, Simon Property Group and Giving Good by Blackhawk Network.

Giving Tuesday aligns with the St. Jude Thanks and Giving campaign, an annual holiday campaign that brings together corporate partners, generous consumers and celebrities to raise funds for the lifesaving mission of St. Jude.