Natural Doctrine's storyline is shown from the perspective of Jeff, the main protagonist, who is accompanied by two females sidekicks, Vasilisa and Anca.

Combat will be based on a turn-based battle system, and a primary concept of gameplay is to have large numbers of allies and enemies simultaneously on a large size battlefield. Time can be controlled dynamically, and units can be controlled in a single space and are able to hide behind objects.

Units in combat against one another form encampments, where units are able to return to camp at the end of the turn as long as the encampment isn't destroyed.

Natural Doctrine will feature single and multiplayer modes with versus/co-operative play, as well as cross-play and cross-save compatible.