Natural Doctrine's storyline is shown from the perspective of Jeff, the main protagonist, who is accompanied by two females sidekicks, Vasilisa and Anca.

Strategy role-playing gamers be ready, as this title will truly test your ability to conquer the evils that lurk in the sprawling networks of mines and ruins in the areas surrounding the fortress city of Feste.

Seasoned explorers and novices alike venture under- ground into dangerous caves to collect the coveted material known as Pluton. During your first trip down into the depths of one of these mines, you and your new explorer friends quickly realize that things may be more dire than you had imagined as you encounter a brand-new type of evil lurking below the surface. You and your newfound friends must strategically defeat these new difficult foes and warn the kingdom of their presence before it’s too late.

Combat will be based on a turn-based battle system, and a primary concept of gameplay is to have large numbers of allies and enemies simultaneously on a large size battlefield. Time can be controlled dynamically, and units can be controlled in a single space and are able to hide behind objects.

Units in combat against one another form encampments, where units are able to return to camp at the end of the turn as long as the encampment isn't destroyed.

Natural Doctrine will feature single and multiplayer modes with versus/co-operative play, as well as cross-play and cross-save compatible.