Featuring online play for the PlayStation 2 and Xbox Live, Area 51 is set in the U.S. government's most top-secret and secure facility located in the Nevada desert. Players take on the role of Lt. Nick Cross, a hazardous biological waste specialist sent to investigate. During his investigation, Lt. Cross stumbles across alien creatures and becomes infected with a biological mutagen that eventually transforms him into something not quite human. To save the earth and himself, Lt. Cross must fight to solve the enigma of Area 51.