As players advance through each stage in Pokémon Rumble Blast, their Toy Pokémon will face dozens of Toy Pokémon at once, creating fast and furious real-time battles. Players must also face off against giant Boss Pokémon, whose massive size and strength offer special challenges. Certain defeated Toy Pokémon can be added to the player’s team, and players may also collect special Toy Pokémon, each with its own unique stats and abilities. Players can collect more than 600 Toy Pokémon in all, including those from the recently released Pokémon Black Version and Pokémon White Version games. Players can quickly and easily switch between the various Toy Pokémon they collect throughout the game.

Pokémon Rumble Blast offers two ways for players to wirelessly connect with each other. Using a local wireless connection, they can enjoy a cooperative play mode that allows them to battle through levels together and more easily befriend defeated Toy Pokémon. Using the Nintendo 3DS StreetPass™ feature, they can challenge the Toy Pokémon of players they pass in their daily travels and view other players’ Mii characters in the game.